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Time-dependent metabolomics uncover dynamic metabolic adaptions in MCF-7 cells exposed to bisphenol A

Frontiers of Environmental Science & Engineering 2023, Volume 17, Issue 1, doi: 10.1007/s11783-023-1604-5

Abstract:

● Metabolomic temporal profiling of cells exposed to xenobiotics.

Keywords： Metabolomics     BPA     MCF-7     Temporal profiling     Metabolic adaption     Dysregulation correlation    

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Mutation profiling of 16 candidate genes in

Yang Zhang, Fang Wang, Xue Chen, Wenjing Liu, Jiancheng Fang, Mingyu Wang, Wen Teng, Panxiang Cao, Hongxing Liu

Frontiers of Medicine 2019, Volume 13, Issue 2,   Pages 229-237 doi: 10.1007/s11684-018-0616-1

Abstract: Mutation profiling of 16 candidate genes were performed in bone marrow samples by using Sanger sequencingThe results showed certain rules in the mutation profiling and concurrence of AML patients, which was

Keywords： leukemia     myeloid     acute     gene     mutation    

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Profiling influences of gene overexpression on heterologous resveratrol production in

Duo Liu,Bingzhi Li,Hong Liu,Xuejiao Guo,Yingjin Yuan

Frontiers of Chemical Science and Engineering 2017, Volume 11, Issue 1,   Pages 117-125 doi: 10.1007/s11705-016-1601-3

Abstract: Metabolic engineering of heterologous resveratrol production in faces challenges as the precursor L-tyrosine is stringently regulated by a complex biosynthetic system. We overexpressed the main gene targets in the upstream pathways to investigate their influences on the downstream resveratrol production. Single-gene overexpression and DNA assembly-directed multigene overexpression affect the production of resveratrol as well as its precursor -coumaric acid. Finally, the collaboration of selected gene targets leads to an optimal resveratrol production of 66.14±3.74 mg·L , 2.27 times higher than the initial production in YPD medium (4% glucose). The newly discovered gene targets expressing phosphoribosylanthranilate isomerase, expressing 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase, and expressing 4-coumaryl-CoA ligase show notable positive impacts on resveratrol production in .

Keywords： resveratrol     aromatic amino acid     DNA assembly     metabolic engineering     gene overexpression    

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Realtime prediction of hard rock TBM advance rate using temporal convolutional network (TCN) with tunnel

Zaobao LIU; Yongchen WANG; Long LI; Xingli FANG; Junze WANG

Frontiers of Structural and Civil Engineering 2022, Volume 16, Issue 4,   Pages 401-413 doi: 10.1007/s11709-022-0823-3

Abstract: This paper proposes a real-time predictive model of TBM advance rate using the temporal convolutional

Keywords： hard rock tunnel     tunnel bore machine advance rate prediction     temporal convolutional networks     soft    

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Temporal trend of mortality from major cancers in Xuanwei, China

Hualiang Lin,Bofu Ning,Jihua Li,Guangqiang Zhao,Yunchao Huang,Linwei Tian

Frontiers of Medicine 2015, Volume 9, Issue 4,   Pages 487-495 doi: 10.1007/s11684-015-0413-z

Abstract: This study aimed to investigate the temporal trend of eight major cancers in Xuanwei County using dataThe temporal trend could be partly explained by changes in risk factors, but it also may be due to theFurther epidemiological studies are warranted to systematically examine the underlying reasons for the temporal

Keywords： cancer     mortality     Xuanwei     temporal trend    

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The temporal changes of the concentration level of typical toxic organics in the river sediments around

Qiang Li, Xiong Xu, Yaoyao Fang, Ruiyang Xiao, Donghong Wang, Wenjue Zhong

Frontiers of Environmental Science & Engineering 2018, Volume 12, Issue 6, doi: 10.1007/s11783-018-1054-7

Abstract:

The current situation of typical organics in the sediments around Beijing was unclear.

56 kinds of typical toxic organics were detected in this article.

Historical data was compared with the data in this study.

The change of different organics in the sediments around Beijing was concluded.

Keywords： Organic compounds     Endocrine disrupters     Sediments     Concentration     Temporal changes    

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Spatio-temporal variations of water quality in Yuqiao Reservoir Basin, North China

Yuan XU,Ruqin XIE,Yuqiu WANG,Jian SHA

Frontiers of Environmental Science & Engineering 2015, Volume 9, Issue 4,   Pages 649-664 doi: 10.1007/s11783-014-0702-9

Abstract: to analyze the water quality status of Yuqiao Reservoir Basin, North China, for assessing its spatio-temporalaffecting spatial variations, and Temp, pH and NO -N were identified as significant variables affecting temporal

Keywords： Fuzzy comprehensive assessment     multivariate statistical analysis     water quality    

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The effect of texture and irrigation on the soil moisture vertical-temporal variability in an urban artificial

Xiaofeng ZHANG,Xu ZHANG,Guanghe LI

Frontiers of Environmental Science & Engineering 2015, Volume 9, Issue 2,   Pages 269-278 doi: 10.1007/s11783-014-0672-y

Abstract: Soil moisture variability in natural landscapes has been widely studied; however, less attention has been paid to its variability in the urban landscapes with respect to the possible influence of texture stratification and irrigation management. Therefore, a case study was carried out in the Beijing Olympic Forest Park to continuously monitor the soil in three typical profiles from 26 April to 11 November 2010. The texture stratification significantly affected the vertical distribution of moisture in the non-irrigated profile where moisture was mostly below field capacity. In the profile where irrigation was sufficient to maintain moisture above field capacity, gravity flow led to increased moisture with depth and thus eliminated the influence of texture. In the non-irrigated sites, the upper layer (above 80 cm) exhibited long-term moisture persistence with the time scale approximating the average rainfall interval. However, a coarse-textured layer weakened the influence of rainfall, and a fine-textured layer weakened the influence of evapotranspiration, both of which resulted in random noise-like moisture series in the deeper layers. At the irrigated site, frequent irrigation neutralized the influence of evapotranspiration in the upper layer (above 60 cm) and overshadowed the influence of rainfall in the deeper layer. As a result, the moisture level in the upper layer also behaved as a random noise-like series; whereas due to deep transpiration, the moisture of the deep layer had a persistence time-scale longer than a month, consistent with characteristic time-scales found for deep transpiration.

Keywords： moisture vertical distribution     moisture temporal variation     texture stratification     irrigation     meteorological    

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Spatial and Temporal Distribution of PM

Xiao-hong Chen,Xiang-bo Tang

Frontiers of Engineering Management 2016, Volume 3, Issue 2,   Pages 171-181 doi: 10.15302/J-FEM-2016017

Abstract: Utilizing the initial hourly monitoring data of PM concentrations at 23 monitoring sites across the Chang-Zhu-Tan city cluster between January 2013 and February 2014 that released in Real-time Air Quality Reporting System in Hunan Province, this paper draws diagrams and analyzes the change rule of the pollutants concentration over time. In addition, this paper studies the regional distribution of PM seasonal pollution in the vicinity of the monitoring sites using ArcGIS geographic information system with the Kriging interpolation method. On this basis, this paper puts forward some effective control strategies to cope with regional PM pollution combined with the information of industry distribution and development status in the Chang-Zhu-Tan city cluster.

Keywords： PM2.5     spatial and temporal distribution     ArcGIS     the chang-Zhu-Tan city cluster    

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Comprehensive profiling of EBV gene expression in nasopharyngeal carcinoma through paired-end transcriptome

Lijuan Hu,Zhirui Lin,Yanheng Wu,Juqin Dong,Bo Zhao,Yanbing Cheng,Peiyu Huang,Lihua Xu,Tianliang Xia,Dan Xiong,Hongbo Wang,Manzhi Li,Ling Guo,Elliott Kieff,Yixin Zeng,Qian Zhong,Musheng Zeng

Frontiers of Medicine 2016, Volume 10, Issue 1,   Pages 61-75 doi: 10.1007/s11684-016-0436-0

Abstract:

The latent expression pattern of Epstein-Barr Virus (EBV) genes in nasopharyngeal carcinoma (NPC) has been extensively investigated, and the expression of several lytic genes in NPC has been reported. However, comprehensive information through EBV transcriptome analysis in NPC is limited. We performed paired-end RNA-seq to systematically and comprehensively characterize the expression of EBV genes in NPC tissue and C666-1 NPC cell line, which consistently carries EBV. In addition to the transcripts restricted to type II latency infection, the type III latency EBNA3s genes and a substantial number of lytic genes, such as BZLF1, BRLF1, and BMRF1, were detected through RNA-seq and were further verified in C666-1 cells and NPC tissue through real-time PCR. We also performed clustering analysis to classify NPC patient groups in terms of EBV gene expression, which presented two subtypes of NPC samples. Results revealed interesting patterns of EBV gene expression in NPC patients. This clustering was correlated with many signaling pathways, such as those related to heterotrimeric G-protein signaling, inflammation mediated by chemokine and cytokine signaling, ribosomes, protein metabolism, influenza infection, and ECM-receptor interaction. Our combined findings suggested that the expression of EBV genes in NPC is restricted not only to type II latency genes but also to type III latency and lytic genes. This study provided further insights into the potential role of EBV in the development of NPC.

Keywords： Epstein-Barr virus     paired-end transcriptome sequencing     latency genes     lytic genes     nasopharyngeal carcinoma    

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Profiling and annotation combined method formultimedia application specificMPSoCperformance estimation

Kai HUANG,Xiao-xu ZHANG,Si-wen XIU,Dan-dan ZHENG,Min YU,De MA,Kai HUANG,Gang CHEN,Xiao-lang YAN

Frontiers of Information Technology & Electronic Engineering 2015, Volume 16, Issue 2,   Pages 135-151 doi: 10.1631/FITEE.1400239

Abstract: Accurate and fast performance estimation is necessary to drive design space exploration and thus support important design decisions. Current techniques are either time consuming or not accurate enough. In this paper, we solve these problems by presenting a hybrid method for multimedia multiprocessor system-on-chip (MPSoC) performance estimation. A general coverage analysis tool GNU gcov is employed to profile the execution statistics during the native simulation. To tackle the complexity and keep the analysis and simulation manageable, the orthogonalization of communication and computation parts is adopted. The estimation result of the computation part is annotated to a transaction accurate model for further analysis, by which a gradual refinement of MPSoC performance estimation is supported. The implementation and its experimental results prove the feasibility and efficiency of the proposed method.

Keywords： MPSoC     Gradual refinement     Native simulation     Performance estimation     Profiling     Annotation     Gcov    

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CLIMATE-CHANGE-INDUCED TEMPORAL VARIATION IN PRECIPITATION INCREASES NITROGEN LOSSES FROM INTENSIVE CROPPING

Frontiers of Agricultural Science and Engineering 2022, Volume 9, Issue 3,   Pages 457-464 doi: 10.15302/J-FASE-2022452

Abstract:

● A simple model was used to evaluate how increasing temporal variability

Keywords： crop yield     fertilizer timing     nitrogen loss     precipitation variability     toy model    

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Machine learning for detecting mesial temporal lobe epilepsy by structural and functional neuroimaging

Baiwan Zhou, Dongmei An, Fenglai Xiao, Running Niu, Wenbin Li, Wei Li, Xin Tong, Graham J Kemp, Dong Zhou, Qiyong Gong, Du Lei

Frontiers of Medicine 2020, Volume 14, Issue 5,   Pages 630-641 doi: 10.1007/s11684-019-0718-4

Abstract: Mesial temporal lobe epilepsy (mTLE), the most common type of focal epilepsy, is associated with functional

Keywords： mesial temporal lobe epilepsy     functional magnetic resonance imaging     structural magnetic resonance imaging    

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Assessment of temporal and spatial variations in water quality using multivariate statistical methods

Xue LI,Pengjing LI,Dong WANG,Yuqiu WANG

Frontiers of Environmental Science & Engineering 2014, Volume 8, Issue 6,   Pages 895-904 doi: 10.1007/s11783-014-0736-z

Abstract: This study evaluated the temporal and spatial variations of water quality data sets for the Xin'anjiangDA identified three significant parameters (temperature, pH and ) to distinguish temporal groups with

Keywords： Xin'anjiang River     multivariable statistical analysis     temporal variation     spatial variation     water quality    

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Distribution and temporal variability of the solar resource at a site in south-east Norway

Muyiwa S. ADARAMOLA

Frontiers in Energy 2016, Volume 10, Issue 4,   Pages 375-381 doi: 10.1007/s11708-016-0426-6

Abstract: Globally, solar energy is expected to play a significant role in the changing face of energy economies in the near future. However, the variability of this resource has been the main barrier for solar energy development in most locations around the world. This paper investigated the distribution and variability of solar radiation using the a 10-year (2006 to 2015) data collected at Sørås meteorological station located at latitude 59° 39′ N and longitude 10° 47′E, about 93.3 m above sea level (about 30 km from Oslo), in south-eastern part of Norway. It is found that on annual basis, the total number of days with a global solar radiation of less than 1 kWh/(m ·d) is 120 days while the total number of days with an expected global solar radiation greater than 3 kWh/(m ·d) is 156 days (42.74%) per year. The potential energy output from a horizontally placed solar collector in these 156 days is approximately 75% of the estimated annual energy output. In addition, it is found that the inter-annual coefficient of variation of the global solar radiation is 4.28%, while that of diffuse radiation is 4.96%.

Keywords： coefficient of variation     global solar radiation     diffuse ratio     albedo     PV energy systems    

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Title Author Date Type Operation

Time-dependent metabolomics uncover dynamic metabolic adaptions in MCF-7 cells exposed to bisphenol A

Journal Article

Mutation profiling of 16 candidate genes in

Yang Zhang, Fang Wang, Xue Chen, Wenjing Liu, Jiancheng Fang, Mingyu Wang, Wen Teng, Panxiang Cao, Hongxing Liu

Journal Article

Profiling influences of gene overexpression on heterologous resveratrol production in

Duo Liu,Bingzhi Li,Hong Liu,Xuejiao Guo,Yingjin Yuan

Journal Article

Realtime prediction of hard rock TBM advance rate using temporal convolutional network (TCN) with tunnel

Zaobao LIU; Yongchen WANG; Long LI; Xingli FANG; Junze WANG

Journal Article

Temporal trend of mortality from major cancers in Xuanwei, China

Hualiang Lin,Bofu Ning,Jihua Li,Guangqiang Zhao,Yunchao Huang,Linwei Tian

Journal Article

The temporal changes of the concentration level of typical toxic organics in the river sediments around

Qiang Li, Xiong Xu, Yaoyao Fang, Ruiyang Xiao, Donghong Wang, Wenjue Zhong

Journal Article

Spatio-temporal variations of water quality in Yuqiao Reservoir Basin, North China

Yuan XU,Ruqin XIE,Yuqiu WANG,Jian SHA

Journal Article

The effect of texture and irrigation on the soil moisture vertical-temporal variability in an urban artificial

Xiaofeng ZHANG,Xu ZHANG,Guanghe LI

Journal Article

Spatial and Temporal Distribution of PM

Xiao-hong Chen,Xiang-bo Tang

Journal Article

Comprehensive profiling of EBV gene expression in nasopharyngeal carcinoma through paired-end transcriptome

Lijuan Hu,Zhirui Lin,Yanheng Wu,Juqin Dong,Bo Zhao,Yanbing Cheng,Peiyu Huang,Lihua Xu,Tianliang Xia,Dan Xiong,Hongbo Wang,Manzhi Li,Ling Guo,Elliott Kieff,Yixin Zeng,Qian Zhong,Musheng Zeng

Journal Article

Profiling and annotation combined method formultimedia application specificMPSoCperformance estimation

Kai HUANG,Xiao-xu ZHANG,Si-wen XIU,Dan-dan ZHENG,Min YU,De MA,Kai HUANG,Gang CHEN,Xiao-lang YAN

Journal Article

CLIMATE-CHANGE-INDUCED TEMPORAL VARIATION IN PRECIPITATION INCREASES NITROGEN LOSSES FROM INTENSIVE CROPPING

Journal Article

Machine learning for detecting mesial temporal lobe epilepsy by structural and functional neuroimaging

Baiwan Zhou, Dongmei An, Fenglai Xiao, Running Niu, Wenbin Li, Wei Li, Xin Tong, Graham J Kemp, Dong Zhou, Qiyong Gong, Du Lei

Journal Article

Assessment of temporal and spatial variations in water quality using multivariate statistical methods

Xue LI,Pengjing LI,Dong WANG,Yuqiu WANG

Journal Article

Distribution and temporal variability of the solar resource at a site in south-east Norway

Muyiwa S. ADARAMOLA

Journal Article